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apalutamide will minimize the level or influence of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Keep away from or Use Alternate Drug. Coadministration of apalutamide, a strong CYP3A4 inducer, with prescription drugs which can be CYP3A4 substrates can lead to reduce exposure to those drugs.Some professionals recommend Xanax